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AbstractAbstract
[en] Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy.
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S0168-583X(16)00065-3; Available from http://dx.doi.org/10.1016/j.nimb.2016.01.017; Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms; ISSN 0168-583X;
; CODEN NIMBEU; v. 373; p. 126-139

Country of publication
ABSORPTION, BARYONS, BEAMS, CALCULATION METHODS, CHEMICAL RADIATION EFFECTS, CHEMICAL REACTIONS, CHEMISTRY, CONFIGURATION, DECOMPOSITION, DOSES, ELEMENTARY PARTICLES, ELEMENTS, ENERGY RANGE, FERMIONS, HADRONS, LOSSES, MEDICINE, METALS, MEV RANGE, NUCLEAR MEDICINE, NUCLEIC ACIDS, NUCLEON BEAMS, NUCLEONS, ORGANIC COMPOUNDS, PARTICLE BEAMS, PARTICLES, RADIATION DOSES, RADIATION EFFECTS, RADIOLOGY, REAGENTS, SIMULATION, SORPTION, THERAPY, TRANSITION ELEMENTS
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