[en] In this report the efficacy of extracellular pharmaceutical Gd-DTPA in Binary Radiotherapy was studied. The study was carried out in mice bearing transplantable adenocarcinoma Ca755 using X-ray based contrast enhanced radiotherapy as a practical implementation of Binary Radiotherapy. It was shown that intravenous administration of 0.3 ml of 0.5 M water solution of Gd-DTPA followed by X-irradiation at a dose of 10 Gy provides T/C%=10±3% and leads to complete tumor regression in 25% of mice. - Highlights: • A new approach of using extracellular drugs in Binary Radiotherapy was proposed. • Vascularization of three different transplanted murine tumors was studied. • Significant efficacy of CERT with Gd-DTPA in curing adenocarcinoma Ca755 was shown.