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Obtention and application of recovery coefficients in SUV values to quality control in PET equipment
Oliveira, Cássio Miri; Sá, Lídia V. de; Santana, Priscila do Carmo; Mamede, Marcelo; Silva, Teógenes A. da, E-mail: cassio.miri@unifesp.br, E-mail: lidia@ird.gov.br, E-mail: mamede.mm@gmail.com, E-mail: silvata@cdtn.br
Associacao Brasileira de Energia Nuclear (ABEN), Rio de Janeiro, RJ (Brazil)2017
Associacao Brasileira de Energia Nuclear (ABEN), Rio de Janeiro, RJ (Brazil)2017
AbstractAbstract
[en] The functional imaging technique Positron Emission Tomography (PET) using the radiopharmaceutical fluorodeoxyglucose ("1"8F-FDG) has been demonstrated an important role in the diagnosis and staging of cancer tumors. However, the standard uptake values (SUV) quantification of a 'lesion' or a hot spot is influenced by partial volume effects (PVE). This is particularly important for evaluating solid tumour response to therapy, where SUV quantification could indicate treatment efficiency. The objective of this study was to evaluate the efficiency of "1"8F-FDG uptake correction in two image quantification modes (SUVmaximum and SUVmedium) through recovery coefficients (RC) application. The NEMA/IEC Body Phantom simulator was used and tested for an activity ratio lesion to background of 4:1, and at different acquisition times. The images quantification was performed with OsiriX® software. The obtained RCs were applied to the phantom images. The obtained SUVmedium values corrected by RCs presented satisfactory results, demonstrating small differences (1.1% a 2.3%) in relation to previously known SUVreference values. This did not occur for corrected SUVmaximum values where differences of up to 27.0% were observed between these and SUVreference values. These results demonstrate that the PVE correction by SUVmedium can more adequate to evaluate tumor's uptake. Therefore, this parameter should be used for equipment quality control in order to evaluate the response and degree of agreement between equipment. (author)
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2017; 10 p; INAC 2017: International Nuclear Atlantic Conference; Belo Horizonte, MG (Brazil); 22-27 Oct 2017
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Miscellaneous
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Conference
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ANTIMETABOLITES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, COMPUTERIZED TOMOGRAPHY, CONTROL, DIAGNOSTIC TECHNIQUES, DRUGS, EMISSION COMPUTED TOMOGRAPHY, FLUORINE ISOTOPES, HOURS LIVING RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LIGHT NUCLEI, MOCKUP, NANOSECONDS LIVING RADIOISOTOPES, NUCLEI, ODD-ODD NUCLEI, RADIOISOTOPES, SIMULATION, STRUCTURAL MODELS, TOMOGRAPHY
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