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Matsuda, Hiroshi; Murata, Miho; Mukai, Yohei; Sako, Kazuya; Ono, Hidetoshi; Toyama, Hiroshi; Inui, Yoshitaka; Taki, Yasuyuki; Shimomura, Hideo; Nagayama, Hiroshi; Tateno, Amane; Ono, Kenjiro; Murakami, Hidetomo; Kono, Atsushi; Hirano, Shigeki; Kuwabara, Satoshi; Maikusa, Norihide; Ogawa, Masayo; Imabayashi, Etsuko; Takano, Harumasa; Sato, Noriko; Hatazawa, Jun; Takahashi, Ryosuke2018
AbstractAbstract
[en] The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30-83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30-39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70-79 age group. This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database. (orig.)
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Source
Available from: http://dx.doi.org/10.1007/s00259-018-3976-5
Record Type
Journal Article
Journal
European Journal of Nuclear Medicine and Molecular Imaging; ISSN 1619-7070;
; CODEN EJNMA6; v. 45(8); p. 1405-1416

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ASIA, BETA DECAY RADIOISOTOPES, COMPUTERIZED TOMOGRAPHY, DEVELOPED COUNTRIES, DIAGNOSTIC TECHNIQUES, DRUGS, ELECTRON CAPTURE RADIOISOTOPES, EMISSION COMPUTED TOMOGRAPHY, HOURS LIVING RADIOISOTOPES, INJECTION, INTAKE, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, MANAGEMENT, MATERIALS, MATHEMATICS, MEGA BQ RANGE, MOCKUP, NUCLEI, ODD-EVEN NUCLEI, RADIOACTIVE MATERIALS, RADIOACTIVITY RANGE, RADIOISOTOPES, STATISTICS, STRUCTURAL MODELS, TESTING, TOMOGRAPHY
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