[en] Samarium-153 chelated to ethylene diaminetetramethylenephosphonate (¹⁵³Sm-EDTMP) is one of the most widely used bone seeking radiopharmaceutical that has been approved by the United States Food and Drug Administration. In this study, we have developed a robust electrochemical separation methodology for removal of radionuclidic contaminants of Eu from ¹⁵³Sm produced using natural Sm₂O₃ targets in Dhruva reactor. The conditions for the electrochemical separation have been optimized, and the feasibility of the method, both in terms of yield and the purity of ¹⁵³Sm for preparation of ¹⁵³Sm-EDTMP, has been evaluated. We have developed a viable electrochemical approach for the large-scale purification of ¹⁵³Sm from radionuclidic contaminants of Eu. The present strategy may well be extended for radiochemical separation and purification of other medically important radioisotopes