[en] Cancer is the abnormal cells that can spread to the bone. Examination can be done with bone scan. PSTNT-BATAN Bandung conducted bone investigator radiopharmaceutical research with technetium-99m radionuclides by MDP labelling. This study aims to obtain an estimation of internal dose of ^99mTc-MDP radiopharmaceutical as an investigator metastasis and bone inflammation to humans based the biodistribution of ^99mTc-MDP radiopharmaceutical PSTNT-BATAN production. This research method, biodistribution test of MDP labeling with technetium-99m with intervals of 2,4,6, and 24 hours after injection through intravenous tail on 12 normal mice at a dose injection 5.44 MBq per mice with a purity is 98.49 % ± 25,37. The biodistribution test result obtained percentage pergram injection dose animal organs that converted into percentages injection dose pergram human organs as value input to the software OLINDA/EXM to get a residence-time and internal dose estimation. The results of the dose estimation using OLINDA/EXM obtained a total value estimated effective dose of ^99mTc-MDP (mSv/MBq) for adult males 1,87 x 10^-3 and for adult women is 2,24 x 10^-3. Results a dose estimation of ^99mTc-MDP radiopharmaceutical PSTNT-BATAN production can be used as a guide when the organ doses to be injected in humans. (author)