[en] Iron oxide copper gold uranium (IOCG-U) ore deposits occur in South Australia. Copper from this ore type is typically extracted by crushing, grinding, sulfide flotation, smelting and electrorefining. South Australian IOCG-U ores also contain highly variable concentrations of uranium along with associated radionuclides such as thorium, radium, lead and polonium. Depending on the concentrations and mineralogical associations of these radionuclides, mineral processing may not be capable of producing a copper concentrate where is saleable into the global smelting pool. In these situations, hydrometallurgical treatment could be considered for separating the radionuclides from the copper. Copper metathesis can potentially be used to leach iron and certain radionuclides into solution while precipitating copper, thereby increasing the concentrate grade and purity. Copper metathesis reactions can be undertaken at ambient conditions. However, the rate and extent of the reactions are increased with increasing temperature. In this research the influence of key process parameters on the copper concentration and radionuclide deportment are investigated. Solution and solid phases are assayed with the main mineral phases identified by x-ray diffraction. The samples are also characterized by alpha and gamma spectrometry to measure radionuclide deportment during the metathesis reaction. It was found that uranium and thorium are effectively leached, chloride strongly promotes lead and polonium leaching while radium leaching was not effective at the conditions tested.