[en] Nuclear power can help to address the twin challenges of ensuring reliable energy supplies and curbing greenhouse gas emissions. The 451 nuclear power reactors in operation in 30 countries today supply over 10% of the world’s total electricity and a third of all low-carbon power. Nuclear power will continue to play a key role in the world’s low-carbon energy mix for decades to come. The safe, secure and sustainable management of spent fuel from nuclear power reactors is key to the future of nuclear energy. This challenge is as much for policymakers as for engineers. In fact, technical solutions for the management of spent fuel exist, ranging from reprocessing and recycling, to conditioning spent fuel for disposal in deep underground repositories. Furthermore, research has established the feasibility of advanced processes, such as partitioning and transmutation, which have the potential to further reduce the impact of nuclear waste. The implementation of any selected strategy can take decades. Allocating the necessary resources to implement the strategy is often difficult. The management of spent fuel involves a long-term commitment, and national strategies must be flexible enough to make it possible to integrate new technologies that will enhance and improve the efficiency, safety, security and sustainability of nuclear power.