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[en] To quantify the influence of interventionalist’s experience on procedure time, radiation exposure, and fluoroscopy time during mechanical thrombectomy (MT) in the anterior circulation. Retrospective analysis of an institutional review board−approved stroke database of a comprehensive stroke center focusing on radiation exposure (as per dose area product in Gy × cm, median [IQR]), procedure, and fluoroscopy time (in minutes, median [IQR]) in patients receiving MT in anterior circulation ischemic stroke. Procedures have been assigned according to the interventionalist’s experience in MT into three sequential groups: A = 1–25 procedures, B = 26–50 procedures, and C = more than 50 procedures. Overall, 696 patients have been included in this analysis (A, n = 152; B, n = 151; C, n = 393). Procedure times (A, 86 [54–131]; B, 67 [48–103], p value 0.006), fluoroscopy times (A, 39 [25–72]; B, 32 [20–53], p value 0.001) as well as radiation exposure (A, 148.13 [89.58–243.37]; B, 111.60 [70.49–180.57], p value 0.001) were significantly shorter, respectively lower in group B than in group A. Procedure times (C, 59 [36–99]), fluoroscopy times (C, 31 [16–53]), and radiation exposure (C, 113.91 [68.48–182.88]) in group C were also significantly shorter/lower than in group A (all p values < 0.0001), but comparable with group B (p values 0.071, 0.809, and 0.934). This retrospective analysis demonstrates a significant influence of interventionalist’s experience on procedure time, fluoroscopy time, and radiation exposure in mechanical thrombectomy in the anterior circulation.