[en] A study into the effects of irradiation temperature on the damage structures that form during proton-irradiation has been carried out on two commercial Zr alloys in order to develop a more mechanistic understanding of the effect of niobium on dislocation loop evolution. The two Zr alloys (Zircaloy-2 and Low-Sn ZIRLO™) were proton irradiated to a damage level of ∼2 dpa at 280 °C, 350 °C and 450 °C. Detailed dislocation analysis was carried out using on-axis bright-field scanning transmission electron microscopy combined with spectral imaging and synchrotron x-ray line profile analysis. The analysis revealed a significant difference in the effect of irradiation temperature on loop size between the two alloys. In the case of the Nb-free Zr-alloy (Zircaloy-2), an increase in irradiation temperature results in a marked increase in a-loop diameter, by a factor of ∼7.5 from 280 to 450 °C, and a stark decrease in the dislocation line density. In contrast, the Nb-containing Zr-alloy (Low-Sn ZIRLO™) showed very little variation of loop size and line density over the same radiation temperature range. The STEM-based spectral imaging revealed irradiation-induced nano-clustering found throughout the matrix in Low-Sn ZIRLO™, which is not present in the case of Zircaloy-2. Therefore, it is proposed that Nb plays a crucial role in the evolution of dislocation loops in Zr through the formation of irradiation precipitation throughout the matrix.