[en] Two-dimensional (2D) semiconductors have attracted increasing attention due to their potential application in next generation optoelectronic devices. The chemical vapor deposition (CVD) grown monolayer MoS₂ is widely investigated as photodetector, but low photoresponsivity and slow response time hinder its practical application. In this work, 0D carbon quantum dots (CQDs) are applied to enhance photodetection performance of 2D MoS₂ as efficient and environmental photosensitizer for the first time. The photoresponsivity and detectivity of hybrid photodetector are 377 A W⁻¹ and 1.6  ×  10¹³ Jones under 360 nm illumination, respectively, which are 22 and 7 times higher than pristine MoS₂. The enhanced photoresponse of hybrid photodetector arises from synergetic absorption effect and interlayer excitonic transition of CQDs and MoS₂ layer. The response speed of hybrid photodetector is four times faster than pristine MoS₂ photodetector. Those results pave a way to hybrid 2D–0D MoS₂–CQDs application in high performance photodetector. (paper)