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[en] Highlights: • Screened 2 types zeolites that adsorb indoxyl sulfate out of 10 types of zeolites. • Chose P87 to make PES-P87 composite membranes through a spin-coating process. • P87 membranes' adsorption level of indoxyl sulfate is 550 μg per g membrane. • Electrostatic attraction is the mechanism of P87 in adsorbing indoxyl sulfate. Studies have shown that protein-bound toxins are related to the progression of chronic kidney disease, and to the generation and aggravation of cardiovascular disease. Indoxyl sulfate, an important toxin in causing reno-cardiovascular syndromes, was chosen as a representative of protein-bound toxins. Experiments in this paper show that zeolite–PES membranes can adsorb 550μg indoxyl sulfate per g membranes. Effects of pH and salts on zeolites adsorption of indoxyl sulfate studies indicate that the adsorption mechanism is likely to be electrostatic attraction.