[en] Highlights: • A new example for high pressure studies on fullerene solvates. • The intercalated CS₂ molecules promote the deformation of C₆₀ molecules under pressure. • The stability of CS₂ molecules under pressure is significantly enhanced in C₆₀∗CS₂ solvates. • The intercalated CS₂ molecules can detect the pressure transformation of C₆₀ molecules. High pressure IR study has been carried out on C₆₀∗CS₂ solvates up to 34.8 GPa. It is found that the intercalated CS₂ molecules significantly affect the transformations of C₆₀ molecules under pressure. As a probe, the intercalated CS₂ molecules can well detect the orientational ordering transition and deformation of C₆₀ molecules under pressure. The chemical stability of CS₂ molecules under pressure is also dramatically enhanced due to the spacial shielding effet from C₆₀ molecules around in the solvated crystal. These results provide new insight into the effect of interactions between intercalants and fullerenes on the transformations in fullerene solvates under pressure.