[en] Highlights: • The Euler-Bernoulli beam theory is modified with rippling effects to be applied for modeling of CNTs dynamics. • The Dirichlet and Neumann modes of Casimir force arisen from the electric and magnetic energies is developed. • The differential quadrature method (DQM) is employed to numerically simulate the non-linear partial differential equations. • Damping effects in the low vacuum gas environment is included. The aim of this research work is to address the influences of dispersion forces and rippled configuration on the instability threshold of carbon nanotube (CNT) based nanotweezers. To this end, the Dirichlet and Neumann modes of Casimir force arisen from the electric and magnetic energies is developed for cylinder–cylinder geometry. Moreover, the CNTs rippling deformation which experimentally revealed is included in the Euler-Bernoulli beam model to modify the governing equations. The differential quadrature method (DQM) in conjunction with the 4th-order Runge-Kutta algorithm is employed to numerically simulate the non-linear partial differential equations. It is interestingly demonstrated that these phenomena remarkably affect the electromechanical behavior of nanotweezers fabricated from CNTs. By taking the rippling configuration and Casimir attraction between tubes into account, the pull-in voltage decreases. On the other hand, when the gas damping effect due to low vacuum environment is taken into consideration, the pull-in value increases. The accuracy of the present modeling is compared with those experimentally published in the literature, giving excellent results.