[en] Full text: Preserving the gum's natural barrier function at the point of intervention is of vital importance in preventing bacterial penetration, which can cause local infection and subsequent bone loss, and is thus the deciding factor for the success and long term stability of a dental implant. In medicine this need arises for all medical implants anchored to non-rigid tissue, such as dental implants, heart valves, vascular prostheses, etc. Despite its international success, the use of an artificial tooth root has the deciding disadvantage of promoting further loss of oral hard and soft tissue. The development of special bonding agents demonstrate a forward-looking approach which can, due to their biocompatibility and their power of adhesion, not only provide an effective barrier against the intrusion of bacteria, but can also markedly improve the long term stability of transmucosal implants. The goal was the development of a biocompatible bonding agent based on the mussel adhesive protein Mefp-1 for the fixation of dental implants. The adhesive Mefp-1-peptides had been synthesized by solid-phase-peptide-synthesis and combined with a polymer afterwards. The biocompatibility and the bonding properties of the adhesive were determined in a key experiment. The in vitro tests were performed according to DIN EN ISO 10993 with the animal fibroblast cell line L-929 and primary human fibroblasts. In vitro studies were performed on a subcutane implantation model on CD-1 mice. In order to determine tensile strength, pig gingival were bound to titanium with the target material. Additionally the adsorption properties of the peptides were evaluated by XPS and QCM-D. It can be stated that this biomaterial shows excellent biocompatibility with a very low manifestation or induction of inflammatory cell components. Furthermore, the peptide modification of the biomaterial improved bonding properties in the model. (author)