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[en] A new compact metal-dielectric-metal waveguide system consisting of a stub coupled with a U-cavity is proposed to produce sharp and asymmetric Fano resonance. The transmission properties of the proposed structure are numerically studied by the finite element method and verified by the coupled mode theory. Simulation results reveal that the spectral profile can be easily tuned by adjusting the geometric parameters of the structure. One of the potential application of the proposed structure as a highly efficient plasmonic refractive index nanosensor was investigated with its sensitivity of more than 1000 nm/RIU and a figure of merit of up to 5500. Another application is integrated slow-light device whose group index can be greater than 6. In addition, multiple Fano resonances will occur in the broadband transmission spectrum by adding another U-cavity or (and) stub. The characteristics of the proposed structure are very promising for the highly performance filters, on-chip nanosensors, and slow-light devices. Graphical abstract: .