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Sahoo, Sridhar; Shrivastava, Vandana; Selvam, T Palani; Bakshi, A K; Kumar, Rajesh; Rama, P; Datta, D; Chinnaesakki, S; Saxena, S K; Kumar, Yogendra; Dash, A, E-mail: barcsridhar@gmail.com2019
AbstractAbstract
[en] This paper describes the evaluation of dosimetry characteristics of an in-house developed 177Lu skin patch source for treatment of non-melanoma skin cancer. A 177Lu skin patch source based on Nafion-115 membrane backbone containing 3.46 ± 0.01 mCi of activity was used. Activity measurement of the patch source was based on gamma ray spectrometry using a HPGe detector. The efficiencies of the HPGe detector were fitted using an orthogonal polynomial function. The absorbed dose rate to water at 5 μm depth in water was determined using an extrapolation chamber, EBT3 Gafchromic film and compared with Monte Carlo methods. The correction factors such as Bragg-Gray stopping power ratio of water-to-air and chamber wall material being different from water, needed to be applied on measurements for establishing the dose rate at 5 μm depth, were calculated using the Monte Carlo method. Absorbed dose rate at 5 μm depth in water (surface dose rate) measured using an extrapolation chamber and EBT3 Gafchromic film were 9.9 ± 0.7 and 8.2 ± 0.1 Gy h−1 mCi−1 respectively for the source activity of 3.46 ± 0.01 mCi. The surface dose rate calculated using the Monte Carlo method was 8.7 ± 0.2 Gy h−1 mCi−1, which agrees reasonably well with measurement. The measured dose rate per mCi offers scope for ascertaining treatment time required to deliver the dose for propitious therapeutic outcome. Additionally, on-axis depth dose and lateral dose profiles at 5 μm and 1 mm depth in water phantom were also calculated using the Monte Carlo method. (paper)
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Available from http://dx.doi.org/10.1088/1361-6498/aaeeb6; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, CALCULATION METHODS, DAYS LIVING RADIOISOTOPES, DOSEMETERS, DOSES, FUNCTIONS, GE SEMICONDUCTOR DETECTORS, INTERMEDIATE MASS NUCLEI, IONIZATION CHAMBERS, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LUTETIUM ISOTOPES, MEASURING INSTRUMENTS, MEDICINE, MOCKUP, NUCLEAR MEDICINE, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIATION DETECTORS, RADIATION DOSE DISTRIBUTIONS, RADIATION DOSES, RADIOISOTOPES, RADIOLOGY, RADIOTHERAPY, RARE EARTH NUCLEI, SEMICONDUCTOR DETECTORS, SPATIAL DOSE DISTRIBUTIONS, SPECTROSCOPY, STRUCTURAL MODELS, THERAPY
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