111In-DTPA-d-Phe−1-Asp0-d-Phe1-octreotide exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-d-Phe1-octreotide

Oshima, Nobuhiro; Akizawa, Hiromichi; Kitaura, Hirotake; Kawashima, Hidekazu; Zhao, Songji

doi:10.1016/j.nucmedbio.2017.07.002

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DOI

¹¹¹In-DTPA-d-Phe⁻¹-Asp⁰-d-Phe¹-octreotide exhibits higher tumor accumulation and lower renal radioactivity than ¹¹¹In-DTPA-d-Phe¹-octreotide

Oshima, Nobuhiro; Akizawa, Hiromichi; Kitaura, Hirotake; Kawashima, Hidekazu; Zhao, Songji2017

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AbstractAbstract

[en] ¹¹¹In-DTPA-d-Phe¹-octreotide scintigraphy is an important method of detecting neuroendocrine tumors. We previously reported that a new derivative of ¹¹¹In-DTPA-d-Phe¹-octreotide, ¹¹¹In-DTPA-d-Phe⁻¹-Asp⁰-d-Phe¹-octreotide, accomplished the reduction of prolonged renal accumulation of radioactivity. The aim of this study was to evaluate the tumor accumulation of ¹¹¹In-DTPA-d-Phe⁻¹-Asp⁰-d-Phe¹-octreotide in vitro and in vivo by comparing it with ¹¹¹In-DTPA-d-Phe¹-octreotide.

Primary Subject

RADIOLOGY AND NUCLEAR MEDICINE (S62)

Source

Record Type

Journal Article

Journal

Nuclear Medicine and Biology; ISSN 0969-8051;

; CODEN NMBIEO; v. 54; p. 18-26

Country of publication

United Kingdom

Descriptors (DEI)

IN VITRO, IN VIVO, INDIUM 111, KIDNEYS, NEOPLASMS, RADIOACTIVITY, SOMATOSTATIN

Descriptors (DEC)

BETA DECAY RADIOISOTOPES, BODY, DAYS LIVING RADIOISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, INDIUM ISOTOPES, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MINUTES LIVING RADIOISOTOPES, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIOISOTOPES

LanguageLanguage

English

Reference NumberReference Number

51078423

INIS VolumeINIS Volume

INIS IssueINIS Issue

External URLExternal URL

http://dx.doi.org/10.1016/j.nucmedbio.2017.07.002

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