[en] Objective: To compare the diagnostic value of ⁹⁹Tc^m-MIBI SPECT/CT chest imaging combined with X-ray mammography and to investigate their complementarity. Methods: This study included 83 female patients, including those suspected to have breast nodules and those diagnosed with breast cancer. All patients were examined initially via ⁹⁹Tc^m-MIBI chest SPECT/CT imaging and delayed imaging followed by X-ray mammography, and all data were compared with final pathological results. Results: Among the ⁹⁹Tc^m-MIBI imaging results of the 83 female patients, 52 lesions were revealed by delay images(T/NT ratio > 3.33). The final criterion for diagnosis was based on positive delay imaging. The T/NT ratio between benign and malignant breast lesions was statistically significant(P < 0.05). The sensitivity, specificity, positive predictive value and negative predictive value of diagnosis via ⁹⁹Tc^m-MIBI SPECT/CT chest imaging were 93.33%, 73.68%, 80.77%, and 90.32%, respectively. The sensitivity, specificity, positive predictive value and negative predictive value of X-ray were 64.44%, 73.68%, 74.36%, 63.63%, respectively. ⁹⁹Tc^m-MIBI imaging superior value to diagnosis X-ray mammogragh for breast cancer(χ² = 4.11, P < 0.05), but two methods of consistency spreads(Kappa = 0.217, P < 0.05). Conclusions: The sensitivity and specificity of ⁹⁹Tc^m-MIBI were higher than those of X-ray mammography in diagnosis of early-stage breast cancer. ⁹⁹Tc^m-MIBI imaging offers advantages in detecting virus infection aslar-pacific nodules. It is speculated that detecting regular breast nodules and occult lesions can be improved if these two methods are combined because they are complementary techniques. (authors)