[en] Apoptosis plays a key role in the development and treatment of tumors; thus, the invasive dynamic monitoring of apoptosis is of considerable interest in the management of cancer. At present, ⁹⁹Tc^m-BTAP-Annexin V, ⁹⁹Tc^m-HYNIC-Annexin V, ¹⁸F-ICMT-11, ¹⁸F-CP18, and ¹⁸F-ML-10 have achieved clinical application. Despite their limitations, these agents are superior to conventional imaging technique in the diagnosis and therapeutic monitoring of cancer and can exhibit potential in clinical applications. This review provides an overview of the recent development in apoptosis imaging by using radionuclide-labeled tracers in the management of cancer. (authors)