[en] The Cell Counting Kit-8 (CCK-8) was used to detect the cell survival rate of HaCaT cells. The apoptosis rate and mortality of HaCaT cells were detected using flow cytometry with the Annexin VFITC and PI double labeling method. Autophagosomes and the generation of reactive oxygen species (ROS) in HaCaT cells were monitored by laser scanning confocal microscopy using monodansylcadaverine (MDC) and dichlorodihydrofluorescein diacetate (DCFH-DA) staining, respectively. The expression of LC3B-II, p-AKT, and total AKT protein in HaCaT cells was determined by western blotting. The results showed that HaCaT cell proliferation was inhibited gradually (p < 0.05) after irradiation with a dose of 10∼80 J/cm² UVA. Treatment with resveratrol enhanced the proliferation of UVA-irradiated HaCaT cells (p < 0.01) and decreased their apoptosis rate and mortality (p < 0.05). The expression of LC3B-II protein was increased (p < 0.01) after irradiation with 20 J/cm² UVA for 3∼24 h. After treatment with resveratrol, autophagy was enhanced (p < 0.01), intracellular ROS level was decreased (p < 0.01), and p-AKT expression was significantly increased (p < 0.01) in UVA-irradiated HaCaT cells. These results indicate that resveratrol could reduce UVA-induced proliferative inhibition, apoptosis, and death in HaCaT cells by enhancing the autophagic process and p-AKT protein expression and by reducing ROS production. (authors)