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AbstractAbstract
[en] A 30-day survival rate experiment was carried out, and the assays of peripheral blood leukocytes, bone marrow DNA content, colony forming units of the spleen (CFU-S), and organ index parameters were analyzed to evaluate the protective effect of a nitric oxide-specific scavenger, Fe2+-diethyldithiocarbamate complex (Fe(DETC)2), on radiation-injured mice. The results showed that compared with the irradiation group, the 30 d survival rate, peripheral blood leukocytes, bone marrow DNA content, CFU-S, and organ index were significantly different from those in the mice treated with different doses. In particular, DETC was administered intraperitoneally at a dose of 300 mg/kg, which increased the survival rate by about 43%, and changes in the number of white blood cells, bone marrow DNA content, and CFU-S were statistically significant (p < 0.01). It is suggested that Fe(DETC)2, a nitric oxide scavenger, has a protective effect on radiation-injured mice. (authors)
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Source
1 fig., 3 tabs., 15 refs.; http://dx.doi.org/10.11889/j.1000-3436.2017.rrj.35.040203
Record Type
Journal Article
Journal
Journal of Radiation Research and Radiation Processing; ISSN 1000-3436;
; v. 35(4); [5 p.]

Country of publication
ANIMAL TISSUES, ANIMALS, BIOLOGICAL MATERIALS, BLOOD, BLOOD CELLS, BODY, BODY FLUIDS, CARBAMATES, CARBONIC ACID DERIVATIVES, CARBOXYLIC ACID SALTS, CHALCOGENIDES, CHARGED PARTICLES, CHELATING AGENTS, DOSES, EVALUATION, HEMATOPOIETIC SYSTEM, IONS, MAMMALS, MATERIALS, NITROGEN COMPOUNDS, NITROGEN OXIDES, NUCLEIC ACIDS, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANIC SULFUR COMPOUNDS, ORGANS, OXIDES, OXYGEN COMPOUNDS, RODENTS, VERTEBRATES
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