[en] Shared interests between GIF and the IAEA have been confirmed in annual interface meetings held at the IAEA since 2003. Areas of technical dialogue, coordination and cooperation have been explored in each of these meetings. Increased cooperation was agreed by the participants and represents a major milestone in the long-lasting cooperation between the two organizations. Both organizations presented their work on developing safety standards or safety assessment methodology applicable to novel advanced reactors, and agreed to provide mutual external review and potential participation in safety related activities. They also highlighted the ongoing activities and plans on proliferation resistance and physical protection (PR&PP), which involve a series of crosscutting topics. IAEA experts presented the new initiative to provide national governments, experts and regulators with integrated Agency-wide support on all aspects of Small Modular Reactor (SMR) development, deployment and oversight. They also introduced FRAMES, a new modelling tool for integrated energy systems assessment under development, which helps in quantifying the economic value that nuclear brings to low carbon energy systems and is therefore a valuable tool for informing policy makers and performing techno economic evaluations. GIF representatives provided an update of GIF activities and highlighted recent developments on the six GEN IV systems as well as introduced the new GIF initiative and Task Forces on Non-electrical applications of Nuclear Heat and Advanced Manufacturing and Material Engineering. They can trigger large progress in safety, reliability, and economy of GEN-IV systems, including SMRs. The objectives of the 15th GIF-IAEA Interface Meeting are to: 1) exchange information on the updates and plans of activities on the previously agreed eleven fields of cooperation; 2) discuss on new potential cooperation topics; 3) explore restructuring of cooperation matrix and establish priorities for further consideration.