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Snipes, M.B.; Runkle, G.E.; Muggenburg, B.A.; Hulbert, A.J.
Inhalation Toxicology Research Institute annual report, 1973--19741974
Inhalation Toxicology Research Institute annual report, 1973--19741974
AbstractAbstract
[en] An experiment was designed to examine dispersion and retention patterns for polydisperse aerosols of fused montmorillonite clay particles labeled with 147Pm. Fourteen dogs were exposed and scheduled for serial sacrifice at 0, 8, 64, and 365 days post-exposure. Experimental procedures included producing a series of slices through the thorax at approximately 1 cm intervals and obtaining a series of autoradiograms and 35 mm color transparencies for each set of thorax slices to define (1) the average doses to lung, lung lobes, and other tissues of interest, (2) the number of hot spots of activity per unit volume in the lung, and (3) a size distribution for these hot spots. Comparable data will be analyzed for 4 additional dogs subjected to lavage therapy to remove a portion of the burden from either the left or right lung using 1 or 5 treatments. Totals of 31 to 71 percent of the initial left or right lung burden were removed by the lavage therapy but only preliminary observations are completed on the autoradiography data. (U.S.)
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Source
Boecker, B.B.; Rupprecht, F.C. (eds.); Lovelace Foundation for Medical Education and Research, Albuquerque, N.Mex. (USA); p. 69-73; Dec 1974
Record Type
Report
Literature Type
Progress Report
Report Number
Country of publication
AEROSOLS, ANIMALS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, BODY AREAS, CLEARANCE, COLLOIDS, DISPERSIONS, DOGS, EXCRETION, INTAKE, INTERMEDIATE MASS NUCLEI, ISOTOPES, KINETICS, MAMMALS, MINERALS, NUCLEI, ODD-EVEN NUCLEI, ORGANS, PROMETHIUM ISOTOPES, RADIATION DOSE DISTRIBUTIONS, RADIOISOTOPES, RARE EARTH NUCLEI, RESPIRATORY SYSTEM, SOLS, VERTEBRATES, YEARS LIVING RADIOISOTOPES
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