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AbstractAbstract
[en] The radiosensitivity of DNA molecules in testicular cells from adult male mice in situ was 0.22 single-strand breaks per 1012 daltons of DNA per rad. This was significantly lower than 0.6-0.7 for liver and thymus DNA, and was most likely attributable to a hypoxic condition of testicular cells in situ. Although a majority of the single-strand scissions was quickly rejoined, a significant extent of breaks remained without further rejoining. The presence of remaining breaks was demonstrated not only after 3-6 h of post-irradiation time, but also after irradiation at low dose rates. The remaining breaks might be a slow and/or non-reparable DNA damage
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Record Type
Journal Article
Journal
Mutation Research; v. 36(2); p. 213-221
Country of publication
ANIMALS, BIOLOGICAL EFFECTS, BIOLOGICAL RADIATION EFFECTS, BIOLOGICAL RECOVERY, BODY, ELECTROMAGNETIC RADIATION, ELEMENTS, EXTERNAL IRRADIATION, GENETIC EFFECTS, GONADS, IONIZING RADIATIONS, IRRADIATION, MALE GENITALS, MAMMALS, NONMETALS, NUCLEIC ACIDS, ORGANIC COMPOUNDS, ORGANS, RADIATION EFFECTS, RADIATIONS, RODENTS, VERTEBRATES
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