[en] The acute toxicity, differential distribution in tissue, and elimination of ScCl₃, ⁴⁶ScCl₃, Sc-EDTA and ⁴⁶Sc-EDTA, in mice, has been investigated. The LD₅₀sup(24hr) doses for ScCl₃ were 440 and 24 mg kg^-1 respectively after intraperitioneal and intravenous injection, and 720 and 108 mg kg^-1 respectively for Sc-EDTA. ⁴⁶ScCl₃ was extensively deposited in the liver and the spleen. ⁴⁶Sc-EDTA was rapidly taken up by the kidney with subsequent elimation via the urine. While-body desaturation kinetics for ⁴⁶Sc-EDTA were found to fit a three compartmental model. The fast elimination phase (T1/2 = 12.75 min; K = 0.05540 min^-1) accounted for 74.6% of the dose; the intermediate phase (T1/2 = 40.2 min; K = 0.01722 min^-1) for 21.8%, and the slow (T1/2 = 5351 min; K = 0.00013 min^-1) for 3.6% of the dose. (author)