[en] The project consists of five separate parts each dealing with radioisotopic methods of diagnosis, localization and quantification of acute myocardial infarction in the experimental animal and in man. The radiopharmaceuticals being studied are 99mTc-glucoheptonate, Thallium-201 and 99mTc-human serum albumin. The authors have found in work performed to date that studies of myocardial infarction are feasible within a few hours of onset and that in animals the size of the infarct can be determined from the area of radioactive uptake on the scan. Evidence has also been presented that 99mTc-glucoheptonate may be concentrated in the ischemic zone and that interventions designed to protect ischemic myocardium may produce reduction of scintigraphic infarct size. Studies with Thallium-201 are in earlier stages but appear promising. To date, no actual studies have been performed with 99mTc-human serum albumin but the mathematical techniques required for such procedures are under development