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AbstractAbstract
[en] The authors describe a RIA of the biologically active fraction (N-terminal) of human parathyroid hormone. This homologous test uses antibodies obtained in goats against a N-terminal 1-34 fragment of hPTH synthetised according to the method of Niall and Coll. In this system, natural hPTH of different origin (extracts from parathyroid adenomas, adenomal culture medium, hyperparathyroid plasma, adsorption chromatography extract of normal human plasma) behaved in the same manner as the synthetic reference hormone 1-34 hPTHN. The RIA detected PTH in 65% of the normal subjects and distinguished the normal values from the values of hyperparathyroid patients, which makes it suitable for clinical practice. (AJ)
[de]
Es wird ein RIA des biologisch aktiven Anteils (N-Terminal) von menschlichem Parathyroidhormon beschrieben. Das homologe Verfahren verwendet Ziegen-Antikoerper fuer ein N-Terminal 1-34 Fragment von nach dem Verfahren von Niall und Coll synthetisiertem hPTH. In dem System verhaelt sich natuerliches hPTH unterschiedlichen Ursprungs (Extrakt von Nebenschilddruesenadenomen, Adenomenkulturmedium, hyperparathyroidem Plasma, Adsorptionschromatographieextrakt von normalem menschlichem Plasma) auf die gleiche Weise wie das synthetische Referenzhormon 1-34 hPTH. Der RIA weist PTH bei 65% der Versuchsperson nach und unterscheidet Normalwerte von den bei Hyperparathyreoidismus erhaltenen Werten; er ist somit fuer die klinische Praxis geeignet. (AJ)Original Title
Dosage radioimmunologique du fragment biologiquement actif de l'hormone parathyroidienne humaine
Primary Subject
Source
1977; 19 p; International symposium on radioimmunoassay and related procedures in medicine; Berlin, Germany, F.R; 31 Oct - 4 Nov 1977; IAEA-SM--220/74; 9 figs.; 27 refs.
Record Type
Miscellaneous
Literature Type
Conference
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Country of publication
ANIMALS, BETA DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BLOOD, BODY, BODY FLUIDS, DAYS LIVING RADIOISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, ENDOCRINE GLANDS, GLANDS, HORMONES, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, MAMMALS, MEDICINE, NEOPLASMS, NUCLEI, ODD-EVEN NUCLEI, ORGANS, PEPTIDE HORMONES, PRIMATES, RADIOISOTOPES, TRACER TECHNIQUES, VERTEBRATES
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