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[en] Rabbit duodenal brush-border membrane vesicles were treated in vitro with deoxycholate, glycodeoxycholate, or taurodeoxycholate. Intravesicular [14C]glucose space at equilibrium, 0.54 microliters/mg protein, was reduced by exposure to the three bile salts in a concentration (0.1-5.0 mM)-dependent manner, equatable with increased membrane fragility. Net proton permeability (Pnet), determined by acridine orange fluorescence quenching, was increased from 6.3 x 10(-4) cm/sec in untreated vesicles, by approximately 120, 150, and 170%, by treatment with bile salts at 0.1, 0.5 and 1.0 mM, respectively. The three bile salts were equipotent. The increases in membrane fragility and Pnet were not accompanied by significant increases in membrane fluidity, as assessed from steady-state and time-resolved diphenylhexatriene fluorescence anisotropy. The data demonstrate direct effects of bile salts on duodenal apical membrane fragility and proton permeability that are likely to be early events in bile salt-induced mucosal damage
[en] Highlights: → Use two kinds of circulation media in the solar collector. → Air heating and pebble bed heat storage are applied with different operating modes. → Design parameters of the system are optimized by simulation program. → It is found that the system can meet 32.8% of the thermal energy demand in heating season. → Annual solar fraction aims to be 53.04%. -- Abstract: The application of solar air collectors for space heating has attracted extensive attention due to its unique advantages. In this study, a solar air heating system was modeled through TRNSYS for a 3319 m2 building area. This air heating system, which has the potential to be applied for space heating in the heating season (from November to March) and hot water supply all year around in North China, uses pebble bed and water storage tank as heat storage. Five different working modes were designed based on different working conditions: (1) heat storage mode, (2) heating by solar collector, (3) heating by storage bed, (4) heating at night and (5) heating by an auxiliary source. These modes can be operated through the on/off control of fan and auxiliary heater, and through the operation of air dampers manually. The design, optimization and modification of this system are described in this paper. The solar fraction of the system was used as the optimization parameter. Design parameters of the system were optimized by using the TRNSYS program, which include the solar collector area, installation angle of solar collector, mass flow rate through the system, volume of pebble bed, heat transfer coefficient of the insulation layer of the pebble bed and water storage tank, height and volume of the water storage tank. The TRNSYS model has been verified by data from the literature. Results showed that the designed solar system can meet 32.8% of the thermal energy demand in the heating season and 84.6% of the energy consumption in non-heating season, with a yearly average solar fraction of 53.04%.
[en] Highlights: • Bruggeman effective medium theory gives satisfied results of intrinsic permeability for amorphous-ferroalloy particle. • Two-dimension colored figure, a very strong visual image for the reflection loss property of the material, is provided. • Optimum reflection loss for the composite filled with the particle of 10 μm is −25.6 dB. • The amorphous-ferroalloy particle has a promising prospect in the application of microwave attenuation. - Abstract: The permeability and reflection loss of the composites filled by water-atomized amorphous-ferroalloy particle are investigated in the range of 1–18 GHz. The results show that the granular size strongly influences the permeability and absorbing property of the material. The soft magnetic property of the particle of 10 μm which is of the order of the skin depth differs from that of 40 μm particle. The Bruggeman effective medium theory can well predict the dynamic magnetic properties in high frequency region for the materials. The composite with the 10 μm particle shows excellent performance in high-frequency absorption compared to the one with the bigger size particle. The size-selectable amorphous-ferroalloy particle is one of the promising candidates for microwave absorption applications