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AbstractAbstract
[en] Hepatic blood flow as derermined by radioactive colloidal gold and its correlation with total blood valume are studied in 13 patients with predominantly right-side congestive heart failure. During the phase of cardiac compensation, the following events occur: 1) significant decrease of the half-life of the clearance of radioactive colloidal gold and of the total blood volume; 2) increase of the clearance constant of the radioactive substance and of hepatic blood flow; 3) significantion correlation between the clearance constant and the total blood volume
[pt]
Estuda-se em 13 pacientes com insuficiencia cardiaca congestiva predominantemente direita, o fluxo sanguineo hepatico atraves do ouro coloidal radioativo e sua correlacao com o volume de sangue circulante. Os resultados permitem concluir que, na fase de compensacao cardiaca ocorre: 1) diminuicao significante da meia-vida de depuracao do ouro coloidal radioativo e da volemia; 2) aumento da constante de depuracao de substancia radioativa e do fluxo sanguineo hepatico; 3) correlacao significante entre a constante de depuracao e a volemiaOriginal Title
Fluxo sanguineo hepatico determinado pelo ouro coloidal radioativo na insuficiencia cardico congestiva
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Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 27 p. 179-185

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AbstractAbstract
[en] To evaluated possible alterations of fat metabolism in chronic Chagas's disease, the authors studied 20 patients 10 without visceral involvement and 10 with evident cardiac damage, using an absorption test using triolein labelled with 131I. The different curves of total blood and the lipoprotein fraction radioactivity were analysed in the two groups of patients. The data obtained in both groups were compared with each other and with those referred for normal individuals. The statistical study showed that: 1. for the radioactivity curves, there were no difference between the Chagasic patients with and those without visceral involvement. 2. for the radioactivity curve of the lipoprotein fraction after 24 hours of ingestion of 131I triolein the values obtained for the Chagasic patients were significantly less than those referred for normal individuals in the same of investigation. It is believed that in Chagas' disease may possibly be some disorder in the mechanisms of normal neutral fat utilization
[pt]
Com a finalidade de verificar possiveis perturbacoes na metabolizacao das gorduras na doenca de Chagas, os autores submeteram 20 pacientes chagasicos (10 sem lesao viseral e 10 com lesao cardiaca) a prova de absorcao de trioleina marcada com 131I. Foram analizados diferentes aspectos da curva de radiotividade total do sangue e da fracao lipoproteica, sendo os resultados comparados: 1-entre os dois grupos de chagasicos; 2-entre chagasicos e individuos clinicamente normais. Com a realizacao do estudo estatistico, os resultados permitiram evidenciar: 1-em relacao as curvas de radioatividade, inexistencia de diferencas entre chagasicos com e sem lesao visceral: 2-na 24.a. hora apos a ingestao do trioleina 131I, os chagasicos apresentaram, em relacao a curva de radiotividade da fracao lipoproteica, valores menores que os de individuos clinicamente normais. Diante desses resultados, conclui-se a existencia, na doenca de Chagas, de alteracoes nos mecanismos envolvidos na utilizacao de gorduras neutrasOriginal Title
Metabolismo lipidico na doenca de Chagas. Aspectos das curvas de radioatividade no sangue obtidas apos a ingestao de trioleina marcada com 131I
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Journal Article
Literature Type
Numerical Data
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 29(3); p. 211-215

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BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, DATA, DATA FORMS, DAYS LIVING RADIOISOTOPES, DISEASES, ESTERS, INFECTIOUS DISEASES, INFORMATION, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPES, KINETICS, LIPIDS, NUCLEI, NUMERICAL DATA, ODD-EVEN NUCLEI, OILS, ORGANIC COMPOUNDS, OTHER ORGANIC COMPOUNDS, PERFORMANCE TESTING, RADIOISOTOPES, REACTION KINETICS, TESTING, TRIGLYCERIDES
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Pires, António; Martins, Paula; Pereira, Ana Margarida; Silva, Patricia Vaz; Marinho, Joana; Marques, Margarida; Castela, Eduardo; Sena, Cristina; Seiça, Raquel, E-mail: pires1961@gmail.com2015
AbstractAbstract
[en] Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders. To compare and correlate markers of adiposity to metabolic disturbances, vascular and cardiac morphology in a European pediatric obese cohort. We carried out an observational and transversal analysis in a cohort consisting of 121 obese children of both sexes, between the ages of 6 and 17 years. The control group consisted of 40 children with normal body mass index within the same age range. Markers of adiposity, plasma lipids and lipoproteins, homeostasis model assessment-insulin resistance, common carotid artery intima-media thickness and left ventricular diameters were analyzed. There were statistically significant differences between the control and obese groups for the variables analyzed, all higher in the obese group, except for age, high-density lipoprotein cholesterol and adiponectin, higher in the control group. In the obese group, body mass index was directly correlated to left ventricular mass (r=0.542; p=0.001), the homeostasis model assessment-insulin resistance (r=0.378; p=<0.001) and mean common carotid artery intima-media thickness (r=0.378; p=<0.001). In that same group, insulin resistance was present in 38.1%, 12.5% had a combined dyslipidemic pattern, and eccentric hypertrophy was the most common left ventricular geometric pattern. These results suggest that these markers may be used in clinical practice to stratify cardiovascular risk, as well as to assess the impact of weight control programs
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Source
Available from http://dx.doi.org/10.5935/abc.20140206; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415862; PMCID: PMC4415862; PMID: 25626764; OAI: oai:pubmedcentral.nih.gov:4415862; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 104(4); p. 266-273

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Jeddi, Sajad; Zaman, Jalal; Ghasemi, Asghar, E-mail: ghasemi@endocrine.ac.ir2015
AbstractAbstract
[en] Ischemic postconditioning (IPost) is a method of protecting the heart against ischemia-reperfusion (IR) injury. However, the effectiveness of IPost in cases of ischemic heart disease accompanied by co-morbidities such as hypothyroidism remains unclear. The aim of this study was to determine the effect of IPost on myocardial IR injury in hypothyroid male rats. Propylthiouracil in drinking water (500 mg/L) was administered to male rats for 21 days to induce hypothyroidism. The hearts from control and hypothyroid rats were perfused in a Langendorff apparatus and exposed to 30 min of global ischemia, followed by 120 min of reperfusion. IPost was induced immediately following ischemia. Hypothyroidism and IPost significantly improved the left ventricular developed pressure (LVDP) and peak rates of positive and negative changes in left ventricular pressure (±dp/dt) during reperfusion in control rats (p < 0.05). However, IPost had no add-on effect on the recovery of LVDP and ±dp/dt in hypothyroid rats. Furthermore, hypothyroidism significantly decreased the basal NO metabolite (NOx) levels of the serum (72.5 ± 4.2 vs. 102.8 ± 3.7 μmol/L; p < 0.05) and heart (7.9 ± 1.6 vs. 18.8 ± 3.2 μmol/L; p < 0.05). Heart NOx concentration in the hypothyroid groups did not change after IR and IPost, whereas these were significantly (p < 0.05) higher and lower after IR and IPost, respectively, in the control groups. Hypothyroidism protects the heart from IR injury, which may be due to a decrease in basal nitric oxide (NO) levels in the serum and heart and a decrease in NO after IR. IPost did not decrease the NO level and did not provide further cardioprotection in the hypothyroid group
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Available from http://dx.doi.org/10.5935/abc.20140181; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375657; PMCID: PMC4375657; PMID: 25424164; OAI: oai:pubmedcentral.nih.gov:4375657; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 104(2); p. 136-143

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AbstractAbstract
[en] Dyslipidemia is the primary risk factor for cardiovascular disease, and statins have been effective in controlling lipid levels. Sex differences in the pharmacokinetics and pharmacodynamics of statins contribute to interindividual variations in drug efficacy and toxicity. To evaluate the presence of sexual dimorphism in the efficacy and safety of simvastatin/atorvastatin treatment. Lipid levels of 495 patients (331 women and 164 men) were measured at baseline and after 6 ± 3 months of simvastatin/atorvastatin treatment to assess the efficacy and safety profiles of both drugs. Women had higher baseline levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) compared with men (p < 0.0001). After treatment, women exhibited a greater decrease in plasma TC and LDL-C levels compared with men. After adjustment for covariates, baseline levels of TC and LDL-C influenced more than 30% of the efficacy of lipid-lowering therapy (p < 0.001), regardless of sex. Myalgia [with or without changes in creatine phosphokinase (CPK) levels] occurred more frequently in women (25.9%; p = 0.002), whereas an increase in CPK and/or abnormal liver function was more frequent in in men (17.9%; p = 0.017). Our results show that baseline TC and LDL-C levels are the main predictors of simvastatin/atorvastatin therapy efficacy, regardless of sex. In addition, they suggest the presence of sexual dimorphism in the safety of simvastatin/atorvastatin. The effect of sex differences on receptors, transporter proteins, and gene expression pathways needs to be better evaluated and characterized to confirm these observations
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Source
Available from http://dx.doi.org/10.5935/abc.20140085; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126759; PMCID: PMC4126759; PMID: 25120083; OAI: oai:pubmedcentral.nih.gov:4126759; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 103(1); p. 33-40

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Zhang, Wenchao; Wang, Hui; Zhang, Wei; Lv, Ruijuan; Wang, Zhihao; Shang, Yuanyuan; Zhang, Yun; Zhong, Ming; Chen, Yuguo; Tang, Mengxiong, E-mail: tangmengxiongsdu8@163.com2013
AbstractAbstract
[en] Activin receptor-like kinase 7 (ALK7) is a type I receptor for the TGF-β superfamily and has recently been demonstrated to play an important role in the maintenance of metabolic homeostasis. To investigate the association of the ALK7 gene polymorphism with metabolic syndrome (MetS) and cardiovascular remodeling in MetS patients. The single nucleotide polymorphism rs13010956 in the ALK7 gene was genotyped in 351 Chinese subjects undergoing carotid and cardiac ultrasonography. The associations of the ALK7 gene polymorphism with the MetS phenotype, MetS parameters, and cardiovascular ultrasonic features were analyzed. The rs13010956 polymorphism in the ALK7 gene was found to be significantly associated with the MetS phenotype in females (p < 0.05) and was also significantly associated with blood pressure in the total (p < 0.05) and female populations (p < 0.01). Further analysis revealed that rs13010956 was associated with mean intima-media thickness of the carotid arteries in females (p < 0.05). After control for body mass index, blood pressure, fasting blood glucose, and triglycerides, rs13010956 was also found to be significantly associated with left ventricular mass index in the total (p < 0.05) and female populations (p < 0.05). Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with MetS risk in females and may be involved in cardiovascular remodeling in MetS patients
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Source
Available from http://dx.doi.org/10.5935/abc.20130129; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998149; PMCID: PMC3998149; PMID: 23765385; OAI: oai:pubmedcentral.nih.gov:3998149; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 101(2); p. 134-140

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Junqueira, Adriana; Cicogna, Antônio Carlos; Engel, Letícia Estevam; Aldá, Maiara Almeida; Tomasi, Loreta Casquel de; Giuffrida, Rogério; Giometti, Inês Cristina; Freire, Ana Paula Coelho Figueira; Aguiar, Andreo Fernando; Pacagnelli, Francis Lopes, E-mail: francispacagnelli@unoeste.br2016
AbstractAbstract
[en] Although the beneficial effects of resistance training (RT) on the cardiovascular system are well established, few studies have investigated the effects of the chronic growth hormone (GH) administration on cardiac remodeling during an RT program. To evaluate the effects of GH on the morphological features of cardiac remodeling and Ca2+ transport gene expression in rats submitted to RT. Male Wistar rats were divided into 4 groups (n = 7 per group): control (CT), GH, RT and RT with GH (RTGH). The dose of GH was 0.2 IU/kg every other day for 30 days. The RT model used was the vertical jump in water (4 sets of 10 jumps, 3 bouts/wk) for 30 consecutive days. After the experimental period, the following variables were analyzed: final body weight (FBW), left ventricular weight (LVW), LVW/FBW ratio, cardiomyocyte cross-sectional area (CSA), collagen fraction, creatine kinase muscle-brain fraction (CK-MB) and gene expressions of SERCA2a, phospholamban (PLB) and ryanodine (RyR). There was no significant (p > 0.05) difference among groups for FBW, LVW, LVW/FBW ratio, cardiomyocyte CSA, and SERCA2a, PLB and RyR gene expressions. The RT group showed a significant (p < 0.05) increase in collagen fraction compared to the other groups. Additionally, the trained groups (RT and RTGH) had greater CK-MB levels compared to the untrained groups (CT and GH). GH may attenuate the negative effects of RT on cardiac remodeling by counteracting the increased collagen synthesis, without affecting the gene expression that regulates cardiac Ca"2"+ transport
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Source
Available from http://dx.doi.org/10.5935/abc.20160003; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728591; PMCID: PMC4728591; PMID: 26647722; OAI: oai:pubmedcentral.nih.gov:4728591; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 106(1); p. 18-25

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AbstractAbstract
[en] Thirty patients with precordial pain and mitral valve prolapse diagnosed by cineangiography and M-mode echocardiography were submitted to Thallium-201 myocardial stress perfusion scintillography. They were divided into two groups: group I - eighteen patients with mitral valve prolapse and normal coronary arteries, of which ten presented positive exercise stress test (55.6%); eight patients had a negative exercise test. Thallium-201 myocardial stress perfusion scintillagraphy was normal in 14 (77.8%) patients, and four with positive stress perfursion scintillography, (three with inferior perfusion defects and one with a lateral one); group II - twelve patients with mitral valve prolapse and severe coronary artery disease (stenosis >= 60% in at least one main vessel of the coronary circulation), of which nine presented positive exercise stress test (75%) and three negative. Thallium-201 exercise myocardial perfusion scintillography was abnormal in nine (75%), six with stress induced ischemia and three with resting defect. Myocardial perfusion scintillography with Thallium-201 was more sensitive to detect the presence of coronary artery disease in patients with mitral valve prolapse (MVP) than the exercise stress test in spite of the fact that a small number of patients (22%) with MVP and normal coronary arteries exhibited abnormal myocardial stress perfusion during scintillography. (Author)
[pt]
Trinta pacientes com dor precordial e prolapso da valva mitral a cineangiografia e ao ecocardiograma modo-M foram submetidos a cintigrafia do miocardio com talio-201 (201Tl) associado ao teste ergometrico (TE). Os pacientes foram assim distribuidos: grupo I (GR I) - 18 pacientes portadores de prolapso da valva mitral com arterias coronarias normais, dos quais 10 apresentavam TE positivo (55,6%) e 8 negativos; a cintigrafia do miocardio com 201Tl foi normal em 14 pacientes (77,8%); 4 apresentaram isquemia transitoria (3 em parede inferior e 1 em parede lateral); grupo II (GR II) - constituido por 12 pacientes com prolapso da valva mitral e doenca obstrutiva coronariana grave (lesoes >= 60% em pelo menos um vaso principal da circulacao coronaria), dos quais 9 apresentavam TE positivo (75%) e 3 negativo. A cintigrafia do miocardio com 201Tl apresentou defeitos de captacao em 9 (75%), sendo 6 com isquemia transitoria e 3 definitiva; nos outros 3 pacientes o mapeamento foi normal. Conclui-se que a cintigrafia do miocardio com 201Tl foi mais sensivel para detectar presenca de doenca obstrutiva coronariana em portadores de prolapso da valva mitral (PVM) que o TE, apesar de um pequeno numero (22,2%) de pacientes com PVM e coronarias normais exibir defeitos de captacao do radioindicador. (Autor)Original Title
Cintigrafia do miocardio com Talio - 201 em pacientes com prolapso da valva mitral, com e sem coronariopatia
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Record Type
Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 36(6); p. 377-386

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ANEMIAS, ARTERIES, BETA DECAY RADIOISOTOPES, BLOOD VESSELS, BODY, CARDIOVASCULAR DISEASES, CARDIOVASCULAR SYSTEM, COUNTING TECHNIQUES, DAYS LIVING RADIOISOTOPES, DIAGNOSTIC TECHNIQUES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, HEART, HEAVY NUCLEI, HEMIC DISEASES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MUSCLES, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIOISOTOPE SCANNING, RADIOISOTOPES, SECONDS LIVING RADIOISOTOPES, SYMPTOMS, THALLIUM ISOTOPES
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AbstractAbstract
[en] The diagnostic accuracy of 64-slice MDCT in comparison with IVUS has been poorly described and is mainly restricted to reports analyzing segments with documented atherosclerotic plaques. We compared 64-slice multidetector computed tomography (MDCT) with gray scale intravascular ultrasound (IVUS) for the evaluation of coronary lumen dimensions in the context of a comprehensive analysis, including segments with absent or mild disease. The 64-slice MDCT was performed within 72 h before the IVUS imaging, which was obtained for at least one coronary, regardless of the presence of luminal stenosis at angiography. A total of 21 patients were included, with 70 imaged vessels (total length 114.6 ± 38.3 mm per patient). A coronary plaque was diagnosed in segments with plaque burden > 40%. At patient, vessel, and segment levels, average lumen area, minimal lumen area, and minimal lumen diameter were highly correlated between IVUS and 64-slice MDCT (p < 0.01). However, 64-slice MDCT tended to underestimate the lumen size with a relatively wide dispersion of the differences. The comparison between 64-slice MDCT and IVUS lumen measurements was not substantially affected by the presence or absence of an underlying plaque. In addition, 64-slice MDCT showed good global accuracy for the detection of IVUS parameters associated with flow-limiting lesions. In a comprehensive, multi-territory, and whole-artery analysis, the assessment of coronary lumen by 64-slice MDCT compared with coronary IVUS showed a good overall diagnostic ability, regardless of the presence or absence of underlying atherosclerotic plaques
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Source
Available from http://dx.doi.org/10.5935/abc.20140211; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415868; PMCID: PMC4415868; PMID: 25626760; OAI: oai:pubmedcentral.nih.gov:4415868; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 104(4); p. 315-323

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ANESTHETICS, ANTICONVULSANTS, ARTERIES, AZINES, BARBITURATES, BLOOD VESSELS, BODY, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM AGENTS, CENTRAL NERVOUS SYSTEM DEPRESSANTS, DIAGNOSTIC TECHNIQUES, DRUGS, HETEROCYCLIC COMPOUNDS, HYPNOTICS AND SEDATIVES, MEDICINE, NUCLEAR MEDICINE, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANIC OXYGEN COMPOUNDS, ORGANS, PYRIMIDINES, RADIOLOGY, TOMOGRAPHY, UNITS
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Campos, Dijon Henrique Salomé; de; Leopoldo, André; Soares; Lima-Leopoldo, Ana Paula; Nascimento, André; Ferreira do; Oliveira-Junior, Silvio Assis de; Silva, Danielle Cristina Tomaz da; Sugizaki, Mario Mateus; Padovani, Carlos Roberto; Cicogna, Antonio Carlos, E-mail: dijoncampos@gmail.com, E-mail: dijoncampos@gmail.com2014
AbstractAbstract
[en] Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished. Study the energy balance of the myocardium with the hypothesis that the increase in fatty acid oxidation and reduced glucose leads to cardiac dysfunction in obesity. 30-day-old male Wistar rats were fed standard and hypercaloric diet for 30 weeks. Cardiac function and morphology were assessed. In this paper was viewed the general characteristics and comorbities associated to obesity. The structure cardiac was determined by weights of the heart and left ventricle (LV). Myocardial function was evaluated by studying isolated papillary muscles from the LV, under the baseline condition and after inotropic and lusitropic maneuvers: myocardial stiffness; postrest contraction; increase in extracellular Ca2+ concentration; change in heart rate and inhibitor of glycolytic pathway. Compared with control group, the obese rats had increased body fat and co-morbities associated with obesity. Functional assessment after blocking iodoacetate shows no difference in the linear regression of DT, however, the RT showed a statistically significant difference in behavior between the control and the obese group, most notable being the slope in group C. The energy imbalance on obesity did not cause cardiac dysfunction. On the contrary, the prioritization of fatty acids utilization provides protection to cardiac muscle during the inhibition of glycolysis, suggesting that this pathway is fewer used by obese cardiac muscle
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Source
Available from http://dx.doi.org/10.5935/abc.20140135; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206364; PMCID: PMC4206364; PMID: 25352507; OAI: oai:pubmedcentral.nih.gov:4206364; This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Arquivos Brasileiros de Cardiologia; ISSN 0066-782X;
; v. 103(4); p. 330-337

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