[en] The publication has been set up as the abstracts of the conference dealing with nuclear medicine problems. The book consists of the sections: (1) Introduction lectures; (2) Technologists; (3) Cardiology; (4) Oncology; (5) Radiation hygiene and physics; (6) Radiopharmaceuticals; (7) Miscellaneous; (8) Poster section

No abstract available

[en] The compound (+-)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]selenazole (1-selenotetramisole) was prepared from 2-aminoselenazoline in a three-step synthetic sequence. Resolution with d-10-camphorsulfonic acid yielded the optical isomers which were compared with (+)- and (-)-tetramisole as inhibitors of alkaline phosphatase isoenzymes. At 8.7 x 10^-5 M the (-) isomer of both tetramisole and 1-selenotetramisole produced significant inhibition of bovine liver and placental isoenzymes but not of calf intestinal or human placental isoenzymes. The (+) isomers demonstrated no inhibition at these concentrations. The similarity in inhibitory activity of the (-) isomers indicates the virtual interchangeability of selenium for sulfur for sulfur in the thiazolidine ring of the parent drug and the likelihood that ⁷⁵Se-radiolabeled selenotetramisole can provide an in vivo tracer to tetramisole biodistribution

No abstract available

[en] The role of nuclear medicine in diagnosis and therapy and its many applications in clinical practice are discussed. (VJ)

[en] Short note

[en] Short communication

[en] This paper collects the scientific research carried out in nuclear medicine in Ecuador. The main topics are: magnetic resonance on intractable epilepsy and on perthes diseases; osseous gammagraphy on diagnostic imaging; arthritis; intracranial lesions treatment, bone scanning, etc

[en] The development of new diagnosis methods, allows at present to evaluate with more accuracy lesions that appear in the spinal column and spinal cord metastasis. We report the review of 1996-1997 clinical cases from our hospital standing out the main parameters as age, regional localization, etc. Although conventional radiography and myelography are useful to identify the metastases aspects and compromise, such studies have been now replaced mostly by computed tomography and magnetic resonance imaging. Computed tomography provides specific data from the osseous component as cortical bone erosions, pathological fractures, classified deposits, trabecular bone confusion. However, sensibility increases in magnetic resonance imaging to assess metastatic infiltration of the marrow, medulary compression, in addition to obtain axial, sagital and coronal sections. The use of contrast mediums help to identify other of these lesions. (The author)

[en] The ³¹P NMR method was first applied to characterize in vivo phosphorylation of H1 and H5 in calf thymus and chicken erythrocytes as well as in vitro phosphorylation of H1 and H5 by cAMP-dependent protein kinase. The amino acid residues phosphorylated in vivo in the histones were exclusively serine residues, and the mole fraction of phosphoserine was estimated to be 0.34 and 0.27 per molecule of calf thymus H1 and chicken erythrocyte H5, respectively. Interestingly, chicken erythrocyte H1 was not phosphorylated in vivo. Three H1 subtypes from calf thymus H1 varied in the ³¹P NMR spectra, and the bisected fragments of calf thymus H1 and chicken erythrocyte H5 exhibited characteristic spectral patterns, indicating that there are considerable diversities of the degree of phosphorylation and phosphorylation sites in very-lysine-rich histones. Furthermore, it was found that the microenvironment of phosphoserine residues phosphorylated in vivo in calf thymus H1 and chicken erythrocyte H5 is quite distinct from that of phosphoserine residues phosphorylated in vitro by bovine heart cAMP-dependent protein kinase. (author)