Published February 1994
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Determination of the chemical and radiochemical purity and specific radioactivity of [18F]FDG by HPLC
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Description
High performance liquid chromatography (HPLC) in combination with the radioactivity detection is the best control method for the radiochemical purity of [18F]FDG. An anion exchange separation mechanism allows isocratic separation of carbohydrates. Using a strong basic eluent, the weakly acid carbohydrates form anions and are therefore retained on the anion exchange resin. The chemical and radiochemical purity and specific radioactivity can be determined simultaneously by including in the chromatographic system a mass detector sensitive, enough for quantitative determination of the product species. (orig.)
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Additional details
Publishing Information
- Imprint Title
- Institute of Bioinorganic and Radiopharmaceutical Chemistry. Annual report 1993
- Imprint Pagination
- 171 p.
- Journal Page Range
- p. 17-23.
- Report number
- FZR--32
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 25049062
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- FLUORINE 18; IMPURITIES; LABELLED COMPOUNDS; LIQUID COLUMN CHROMATOGRAPHY; QUALITY CONTROL; QUANTITATIVE CHEMICAL ANALYSIS; RADIOACTIVITY; RADIOCHROMATOGRAPHY; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; CHROMATOGRAPHY; CONTROL; DRUGS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES