Institute of Bioinorganic and Radiopharmaceutical Chemistry. Annual report 1993

The subjects of the present report are described in this volume in 41 reports dealing with various aspects of radiotracers for nuclear medicine. This first part describes synthetic work on 11C-tracers and precursors. The papers on technetium/rhenium chemistry describes the efforts to gain a deeper insight into the reactions taking place in intricate Tc/Re-ligand systems, to design more suitable and variable chelate units, and to start functionalizing these complexes in order to make them mimics of biochemical substrates or drugs. Progress has been achieved in the complexation of SH-containing peptides, mainly by the introduction of N-alkylation, which remarkably influences the properties of the complexes, by systematic alteration of the peptide chain length and derivatization. (orig./EF)