Toxicity and effect of flavellagic acid on blood coagulation and hemostasis in healthy whole-body irradiated rabbits

A single dose of i. v. administered flavellagic acid, 12 mg/kg, did not produce death of rabbits or changes in the number of cells in the peripheral blood flow and of serum proteins. One hour after i. v. administration of flavellagic acid, 0.7 mg/kg to healthy rabbits caused a significant shortening of the bleeding time, an increase in the number of platelets and ma values of the thromboelastographic record. The administration of an equal dose of flavellagic acid to rabbits on the 12th day after whole-body irradiation with 7.0 Gy did nof affect the post-irradiation disorder of hemostasis. (author)