Published March 18, 1981
| Version v1
Journal article
Studies on the effect of superoxide dismutase on radiation-induced changes in the DNA molecule. 3
Description
In order to determine the difference between the specific enzymatic influence of superoxide dismutase (SOD) and the unspecific influence of the protein, investigations were carried out under aerobic and anaerobic conditions. The active site of SOD was blocked by CN-. The main method used to determine the postirradiation damages in DNA was the determination of the amount of terminal phosphate released. The investigations carried out under the conditions specified above, lead to the conclusion that SOD acts as enzyme and that O2- participates in the irradiation-induced DNA damages. (author)
Additional details
Additional titles
- Subtitle (English)
- Studies on DNA strand breaks and deoxyribose damages under aerobic and anaerobic conditions
Publishing Information
- Journal Title
- Stud. Biophys.
- Journal Volume
- 82
- Journal Issue
- 3
- Series
- Stud. Biophys.
- Journal Page Range
- 229-235
- ISSN
- 0081-6337
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- German Democratic Republic
- INIS RN
- 13653420
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CATALYSIS; COBALT 60; DEOXYRIBOSE; DNA; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; METABOLISM; OXIDOREDUCTASES; RADIOPROTECTIVE SUBSTANCES; STRAND BREAKS
- Descriptors DEC
- ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOHYDRATES; COBALT ISOTOPES; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; MONOSACCHARIDES; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PENTOSES; RADIATIONS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; SACCHARIDES; YEARS LIVING RADIOISOTOPES