Published December 1976 | Version v1
Journal article Metadata-only

sup(99m)technitium-unithiol complex, a new pharmaceutical for kidney scintigraphy

Creators

Description

The investigations were carried out with a newly synthesised, original sup(99m)Tc-unithiol complex (unithiol-2,3-dimercaptopropansulphonate). It accumulates in the kidneys and enables their scintigraphic examination at 90-180 minutes after the administration. The study was performed on rats, rabbits and dogs. sup(99m)Tc-unithiol complex accumulation in rat kidneys was 34,9%, 44,5% and 67,8% of dose after 1, 2 and 3 h respectively. Good reability of the scintigraphic picture of the kidneys in rabbits and dogs confirms the accumulative capability of the complex in these organs. It was found by means of ascending paper chromatography that the purity of the sup(99m)Tc-unithiol complex exceeded 90%. (orig.)

Abstract (German)

Die Untersuchungen wurden mit Hilfe eines neu synthetisierten Original sup(99m)Tc-Unithiol-Komplexes (Unithiol-2,3-Dimercaptopropanosulphonat) durchgefuehrt. Dieser wird in den Nieren gespeichert und ermoeglicht deren Szintigraphische Untersuchung 90 bis 180 Minuten nach der Gabe. Die Studie wurde an Ratten, Kaninchen und Hunden vorgenommen. Die sup(99m)Tc-Unithiol-Komplex-Speicherung in Rattennieren betrug 34,9%, 44,5% und 67,8% der verabreichten Dosis nach 1, 2 bzw. 3 Stunden. Die gute Szintigrammwiedergabe der Nieren bei Kaninchen und Hunden bestaetigt die Speicherfaehigkeit dieses Komplexes in diesen Organen. Mit Hilfe der Papierchromatographie wurde festgestellt, dass die Reinheit des sup(99m)Tc-Unithiol-Komplexes 90% ueberstieg. (orig.)

Additional details

Identifiers

DOI
10.1055/s-0038-1624977;

Publishing Information

Journal Title
Nuklearmedizin
Journal Volume
15
Journal Issue
06
Series
Nucl.-Med.
Journal Page Range
282-286
ISSN
0029-5566

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
8306348
Subject category
S60: APPLIED LIFE SCIENCES;
Is Lead record
Yes
Descriptors DEI
BIOLOGICAL HALF-LIFE; DIAGNOSIS; DIAGNOSTIC TECHNIQUES; DOGS; INTRAVENOUS INJECTION; ISOMERIC NUCLEI; KIDNEYS; MICE; RADIOPHARMACEUTICALS; RATS; RENAL CLEARANCE; SCINTISCANNING; TECHNETIUM 99; UNITHIOL
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CLEARANCE; COUNTING TECHNIQUES; DITHIOLS; DRUGS; EXCRETION; HOURS LIVING RADIOISOTOPES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; REAGENTS; RODENTS; SULFONIC ACIDS; TECHNETIUM ISOTOPES; THIOLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
6 figs.; 1 tab.; 16 refs.; Updated automatically by Metadata and Full-Text Enrichment Agent